Anti-Diuretic Hormone (ADH, Vasopressin)

Clinical Significance
Anti-Diuretic Hormone is a hormone released by the neurohypophysis.  It has potent anti-diuretic and vasopressor activities.  It is released with its carrier protein Neurophysin.  Anti-Diuretic Hormone measurement gives a good indicator of posterior pituitary function and activity.  Secretion of Anti-Diuretic Hormone is primarily controlled by the osmotic pressure of the plasma.  Blood pressure, blood volume, nausea, hypoglycemia, and Angiotensin are other factors regulating Anti-Diuretic Hormone secretion.  The most important function of Anti-Diuretic Hormone is the reduction of the rate of urine output. 

Reference Range
Up to 7 pg/ml

Anti-Diuretic Hormone is measured by direct radioimmunoassay.

Patient Preparation
Patient should not be on diuretics, hypertension, or blood pressure medication, if possible, for at least 48 hours prior to collection of specimen.

Specimen Collection
3 ml serum or plasma EDTA should be collected and separated as soon as possible.  Store specimens frozen.  Minimum specimen size is 1 ml. Whole blood not acceptable specimen type.

Special Specimens
For tumor/tissue and various fluids (i.e., CSF, peritoneal, synovial, etc.), contact the Institute for requirements and special handling.

Shipping Instructions
Ship specimens frozen in dry ice.

1. Gavras H.  Role of Vasopressin in Clinical Hypertension and Congestive Cardiac Failure:  Interaction with the Sympathetic Nervous System.  Clin Chem 37:1828-1830, 1991.

2. H Gavras, I Gavras.  Salt-Induced Hypertension: The Interactive Role of Vasopressin and of the Sympathetic Nervous System.  J Hypertens 7: 601-606,1989.

CPT Code: 
Immunoassay  83519