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Inhibin A*

* Test available on a research basis only. Contact ISI for details.

 

Inhibin B*

* Test available on a research basis only. Contact ISI for details.

 

Insulin*

* Test available on a research basis only. Contact ISI for details.

 

Insulin, urine*

* Test available on a research basis only. Contact ISI for details.

 

Interleukin 1a

Clinical Significance:
The Interleukins belong to the family termed cytokines.  They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells.  Interleukin 1a is a 17,500 molecular weight peptide derived primarily from macrophages, fibroblasts, endothelial cells, and B cells.  The major target cells are T and B cells, Fibroblasts, and Hepatocytes.  Interleukin 1a shares a receptor with Interleukin 1b although they are significantly  different structurally.  Interleukin 1a promotes antigen specific immune responses, inflammation, Prostaglandin secretion, Colony Stimulating Factors, proteoglycanase, collagenase, and gelatinase activity, and release of Interleukin 2 from T cells.  Levels are stimulated by liposaccharide, endotoxins, inflammatory agents, lectin, Tumor Necrosis Factor, and Interferons.  Levels are suppressed by Corticosteroids, Prostaglandin E2, and suppressant lymphocytes.

Reference Range:
Reference Range available by report.

Procedure:
Interleukin 1a is measured by direct radioimmunoassay/enzyme immunoassay.

Patient Preparation:
Patient should not be on any Corticosteroids, anti-inflammatory medications or pain killers, if possible, for at least 48 hours prior to collection of specimen.

Specimen Collection:
3 ml serum or EDTA plasma should be collected and separated as soon as possible.  Freeze specimen immediately after separation.  Minimum specimen size is 1 ml.

Special Specimens:
For tumor/tissue and various fluids (i.e. CSF, peritoneal, synovial, etc.) contact the Institute for requirements and special handling.

Shipping Instructions:
Ship specimens frozen in dry ice.

References:
1. JT Whicher and SW Evans.  Cytokines in Disease.  Clinical Chemistry 36: 1269-1281, 1990.

2. MP Bevilacqua, JS Pober, GR Majeau, W Fiers, RS Cotran, and MA Gimbrone.  Recombinant Tumor Necrosis Factor Induced Pro-Coagulant Activity in Cultured Human Vascular Endothelium:  Characterization and Comparison with Action of Interleukin-1.  Proceedings of the National Academy of Science 83: 4533-4537, 1986.

 

Interleukin 1b

Clinical Significance:
The Interleukins belong to the family termed cytokines.  They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells.  Interleukin 1b is a 17,500 molecular weight peptide derived primarily from macrophages, fibroblasts, endothelial cells, and B cells.  The major target cells are T and B cells, Fibroblasts, and Hepatocytes and it has pyrogenic activity.  Interleukin 1b shares a receptor with Interleukin 1a although they are significantly different  structurally.  Interleukin 1b promotes antigen specific immune responses, inflammation, secretion, Colony Stimulating Factors, proteoglycanase, collagenase, and gelatinase activity, acute phase response, and cartilage resorption.  Interleukin 1b increases accumulation of cell-associated and extracellular arachadonic acid, and induces release of Interleukin 6.

Reference Range:
Reference Range available by report.

Procedure:
Interleukin 1b is measured by direct radioimmunoassay/enzyme immunoassay.

Patient Preparation:
Patient should not be on any Corticosteroids, anti-inflammatory medications or pain killers, if possible, for at least 48 hours prior to collection of specimen.

Specimen Collection:
3 ml serum or EDTA plasma should be collected and separated as soon as possible.  Freeze specimen immediately after separation.  Minimum specimen size is 1 ml.

Special Specimens:
For tumor/tissue and various fluids (i.e. CSF, peritoneal, synovial, etc.) contact the Institute for requirements and special handling.

Shipping Instructions:
Ship specimens frozen in dry ice.

References:
1. JT Whicher and SW Evans.  Cytokines in Disease.  Clinical Chemistry 36: 1269-1281, 1990.

2. MP Bevilacqua, JS Pober, GR Majeau, W Fiers, RS Cotran, and MA Gimbrone.  Recombinant Tumor Necrosis Factor Induced Pro-Coagulant Activity in Cultured Human Vascular Endothelium:  Characterization and Comparison with Action of Interleukin-1.  Proceedings of the National Academy of Science 83: 4533-4537, 1986.

 

Interleukin 2*

* Test available on a research basis only. Contact ISI for details.

 

Interleukin 3*

* Test available on a research basis only. Contact ISI for details.

 

Interleukin 4*

* Test available on a research basis only. Contact ISI for details.

 

Interleukin 5*

* Test available on a research basis only. Contact ISI for details.

 

Interleukin 6

Clinical Significance:
The Interleukins belong to the family termed cytokines.  They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells.  Interleukin 6 is a 25,000 molecular weight glycoprotein produced primarily in macrophages, T cells, fibroblasts and endothelial cells.  Its primary target cells are T and B cells and neutrophils.  Its main actions are involvement in terminal differentiation of B cells to antibody secreting plasma cells, activation of T cells and stimulation of hepatocyte production of acute phase proteins.  Interleukin stimulates Prolactin, Growth Hormone, Luteinizing Hormone, Follicle Stimulating Hormone and ACTH.  Release is stimulated by Interleukin 1a and b, Vasoactive Intestinal Polypeptide, and Prostaglandin E2.  Release is not affected by aspirin or indomethacin.  Levels are elevated in multiple myeloma, rheumatoid arthritis, systemic lupus erythematosus, meningococcus meningitis and infectious peritonitis.

Reference Range:
Reference Range available by report.

Procedure:
Interleukin 6 is measured by direct radioimmunoassay/enzyme immunoassay.

Patient Preparation:
Patient should not be on any Corticosteroids, anti-inflammatory medications or pain killers, if possible, for at least 48 hours prior to collection of specimen.

Specimen Collection:
3 ml serum or EDTA plasma should be collected and separated as soon as possible.  Freeze specimen immediately after separation.  Minimum specimen size is 1 ml.

Special Specimens:
For tumor/tissue and various fluids (i.e. CSF, peritoneal, synovial, etc.) contact the Institute for requirements and special handling.

Shipping Instructions:
Ship specimens frozen in dry ice.

References:
1. JT Whicher and SW Evans.  Cytokines in Disease.  Clinical Chemistry 36: 1269-1281, 1990.

2. BL Spangelo, WD Jarvis, AM Judd, and RM MacLeod.  Induction of Interleukin-6 Release by Interleukin-1 in Rat Anterior Pituitary Cells in vitro:  Evidence for an Eicosanoid Dependent Mechanism.  Endocrinology 129: 2886-2894, 1991.

 

Interleukin 7

* Test available on a research basis only. Contact ISI for details.

 

Interleukin 8

Clinical Significance:
The Interleukins belong to the family termed cytokines.  They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells.  Interleukin 8 is a 6,000 - 8000 molecular weight glycoprotein produced primarily by macrophages and monocytes.  Its primary target cells are neutrophils.  Interleukin 8 is a chemotactic agent for monocytes and neutrophils.  Interleukin 8 causes oxygen radical and enzyme release by neutrophils and mobilizes products into circulation.  Interleukin 8 is stimulated by Interleukin 1 and Tumor Necrosis Factor.

Reference Range:
Reference Range available by report.

Procedure:
Interleukin 8 is measured by direct radioimmunoassay/enzyme immunoassay.

Patient Preparation:
Patient should not be on any Corticosteroids, anti-inflammatory medications or pain killers, if possible, for at least 48 hours prior to collection of specimen.

Specimen Collection:
3 ml serum or EDTA plasma should be collected and separated as soon as possible.  Freeze specimen immediately after separation.  Minimum specimen size is 1 ml.

Special Specimens:
For tumor/tissue and various fluids (i.e. CSF, peritoneal, synovial, etc.) contact the Institute for requirements and special handling.

Shipping Instructions:
Ship specimens frozen in dry ice.

References:
1. JT Whicher and SW Evans.  Cytokines in Disease.  Clinical Chemistry 36: 1269-1281, 1990.

2. K Matsushima, JJ Oppenheim.  Interleukin-8 and Macrophage Colony Stimulating Factor:  Novel Inflammatory Cytokines Inducible by Interleukin I and Tumor Necrosis Factor.  Cytokine 1: 2 - 13, 1989.

 

Interleukin 10

Clinical Significance:
The Interleukins belong to the family termed cytokines.  They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells.

Reference Range:
Reference Range available by report.

Procedure:
Interleukin 10 is measured by direct radioimmunoassay/enzyme immunoassay.

Patient Preparation:
Patient should not be on any Corticosteroids, anti-inflammatory medications or pain killers, if possible, for at least 48 hours prior to collection of specimen.

Specimen Collection:
3 ml serum or EDTA plasma should be collected and separated as soon as possible.  Freeze specimen immediately after separation.  Minimum specimen size is 1 ml.

Special Specimens:
For tumor/tissue and various fluids (i.e. CSF, peritoneal, synovial, etc.) contact the Institute for requirements and special handling.

Shipping Instructions:
Ship specimens frozen in dry ice.

References:
1. JT Whicher and SW Evans.  Cytokines in Disease.  Clinical Chemistry 36: 1269-1281, 1990.

2. K Matsushima, JJ Oppenheim.  Interleukin-8 and Macrophage Colony Stimulating Factor:  Novel Inflammatory Cytokines Inducible by Interleukin I and Tumor Necrosis Factor.  Cytokine 1: 2 - 13, 1989.

 

Interleukin 12*

* Test available on a research basis only. Contact ISI for details.

 

Interleukin 13*

* Test available on a research basis only. Contact ISI for details.

 

Interleukin 14 - 17*

* Test available on a research basis only. Contact ISI for details.

 

Interleukin 18*

* Test available on a research basis only. Contact ISI for details.

 

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